FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term glutathione synthase activity ID (Ontology) GO:0004363 (Gene Ontology)
Definition Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate.[ EC:6 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 glutathione synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | glutathione synthase activity
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catalytic activity
 |__non-ribosomal peptide synthetase activity___
ligase activity, forming carbon-nitrogen bonds  |
 |__acid-amino acid ligase activity_____________|
                                                glutathione synthase activity  2 rec.
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Is a acid-amino acid ligase activity
non-ribosomal peptide synthetase activity
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Synonyms
  • "gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)" RELATED[ EC:6 ]
    "glutathione synthetase activity" RELATED[ EC:6 ]
    "GSH synthetase activity" RELATED[ EC:6 ]
Secondary IDs
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EC:6.3.2.3
KEGG_REACTION:R00497
MetaCyc:GLUTATHIONE-SYN-RXN
Reactome:R-HSA-174394 "GSS:Mg2+ dimer synthesizes GSH"
Reactome:R-HSA-5602901 "Defective GSS does not synthesize GSH"
RHEA:13557