FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term glycine hydroxymethyltransferase activity ID (Ontology) GO:0004372 (Gene Ontology)
Definition Catalysis of the reaction: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 glycine hydroxymethyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | glycine hydroxymethyltransferase activity
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  transferase activity, transferring one-carbon groups
   |__hydroxymethyl-, formyl- and related transferase activity
       |__glycine hydroxymethyltransferase activity  1 rec.
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Is a hydroxymethyl-, formyl- and related transferase activity
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Synonyms
  • "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity" RELATED[ EC:2 ]
    "allothreonine aldolase activity" RELATED[ EC:2 ]
    "L-serine hydroxymethyltransferase activity" RELATED[ EC:2 ]
    "serine aldolase activity" RELATED[ EC:2 ]
    "serine hydroxymethylase activity" RELATED[ EC:2 ]
    "serine hydroxymethyltransferase activity" RELATED[ EC:2 ]
    "serine transhydroxymethylase activity" RELATED[ EC:2 ]
Secondary IDs
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MetaCyc:GLYOHMETRANS-RXN
Reactome:R-HSA-5694137 "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser"
RHEA:15481