FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term glycine dehydrogenase (decarboxylating) activity ID (Ontology) GO:0004375 (Gene Ontology)
Definition Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H+ = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 glycine dehydrogenase (decarboxylating) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | glycine dehydrogenase (decarboxylating) activity       --
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  oxidoreductase activity, acting on the CH-NH2 group of donors
   |__oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
       |__glycine dehydrogenase (decarboxylating) activity  2 rec.
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Is a oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
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Synonyms
  • "glycine cleavage system P-protein activity" NARROW[ EC:1 ]
    "glycine decarboxylase activity" RELATED[ EC:1 ]
    "glycine-cleavage complex" RELATED[ EC:1 ]
    "glycine-cleavage complex P-protein activity" RELATED[ EC:1 ]
    "glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)" RELATED[ EC:1 ]
    "glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)" RELATED[ EC:1 ]
    "P-protein" NARROW[ EC:1 ]
    "protein P1" NARROW[ EC:1 ]
Secondary IDs
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EC:1.4.4.2
MetaCyc:GCVP-RXN
Reactome:R-HSA-5693967 "PXLP-K754-GLDC dimer decarboxylates Gly"
RHEA:24304