FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term heme oxygenase (decyclizing) activity ID (Ontology) GO:0004392 (Gene Ontology)
Definition Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase].
Also Known As "haem oxygenase (decyclizing) activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 heme oxygenase (decyclizing) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | heme oxygenase (decyclizing) activity
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monooxygenase activity_________________________________________________________________________________
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen__|
                                                                                         oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
                                                                                          |__heme oxygenase (decyclizing) activity  1 rec.
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Is a oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
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Synonyms
  • "haem oxidase activity" RELATED[ EC:1 ]
    "haem oxygenase (decyclizing) activity" EXACT
    "haem oxygenase activity" RELATED[ EC:1 ]
    "heme oxidase activity" RELATED[ EC:1 ]
    "heme oxygenase activity" RELATED[ EC:1 ]
    "heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)" RELATED[ EC:1 ]
    "ORP33 proteins" RELATED[ EC:1 ]
Secondary IDs
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EC:1.14.14.18
MetaCyc:HEME-OXYGENASE-DECYCLIZING-RXN
Reactome:R-HSA-189398 "HMOX1 dimer, HMOX2 cleave heme"
RHEA:21764