FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term hydroxymethylglutaryl-CoA lyase activity ID (Ontology) GO:0004419 (Gene Ontology)
Definition Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.[ EC:4 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 hydroxymethylglutaryl-CoA lyase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | hydroxymethylglutaryl-CoA lyase activity
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  carbon-carbon lyase activity
   |__oxo-acid-lyase activity
       |__hydroxymethylglutaryl-CoA lyase activity  1 rec.
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Is a oxo-acid-lyase activity
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Synonyms
  • "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)" RELATED[ EC:4 ]
    "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity" RELATED[ EC:4 ]
    "3-hydroxy-3-methylglutarate-CoA lyase activity" RELATED[ EC:4 ]
    "3-hydroxy-3-methylglutaryl CoA cleaving enzyme" RELATED[ EC:4 ]
    "3-hydroxy-3-methylglutaryl coenzyme A lyase activity" RELATED[ EC:4 ]
    "3-hydroxy-3-methylglutaryl-CoA lyase activity" RELATED[ EC:4 ]
    "HMG-CoA lyase activity" RELATED[ EC:4 ]
    "hydroxymethylglutaryl coenzyme A lyase activity" RELATED[ EC:4 ]
    "hydroxymethylglutaryl coenzyme A-cleaving enzyme" RELATED[ EC:4 ]
Secondary IDs
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EC:4.1.3.4
KEGG_REACTION:R01360
MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN
Reactome:R-HSA-6788597 "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA"
Reactome:R-HSA-74180 "HMG CoA => acetoacetic acid + acetyl CoA"
RHEA:24404