FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term hydroxymethylglutaryl-CoA reductase (NADPH) activity ID (Ontology) GO:0004420 (Gene Ontology)
Definition Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH.[ PubMed:29224355 ]
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 hydroxymethylglutaryl-CoA reductase (NADPH) activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | hydroxymethylglutaryl-CoA reductase (NADPH) activity       1
Spanning Tree (Parents/Children)
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  oxidoreductase activity, acting on CH-OH group of donors
   |__oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
       |__hydroxymethylglutaryl-CoA reductase (NADPH) activity  1 rec.
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Is a oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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Synonyms
  • "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD[ EC:1 ]
    "HMG-CoA reductase activity" BROAD[ EC:1 ]
    "hydroxymethylglutaryl-CoA reductase activity" RELATED
Secondary IDs
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EC:1.1.1.34
KEGG_REACTION:R02082
MetaCyc:1.1.1.34-RXN
Reactome:R-HSA-191352 "HMGCR dimer reduces bHMG-CoA to MVA"
RHEA:15989