FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term hydroxymethylglutaryl-CoA synthase activity ID (Ontology) GO:0004421 (Gene Ontology)
Definition Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H+.
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 hydroxymethylglutaryl-CoA synthase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | hydroxymethylglutaryl-CoA synthase activity       1
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  acyltransferase activity
   |__acyltransferase activity, acyl groups converted into alkyl on transfer
       |__hydroxymethylglutaryl-CoA synthase activity  1 rec.
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Is a acyltransferase activity, acyl groups converted into alkyl on transfer
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Synonyms
  • "(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity" RELATED[ EC:2 ]
    "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)" RELATED[ EC:2 ]
    "3-hydroxy-3-methylglutaryl CoA synthetase activity" RELATED[ EC:2 ]
    "3-hydroxy-3-methylglutaryl coenzyme A synthase activity" RELATED[ EC:2 ]
    "3-hydroxy-3-methylglutaryl coenzyme A synthetase activity" RELATED[ EC:2 ]
    "3-hydroxy-3-methylglutaryl-CoA synthase activity" RELATED[ EC:2 ]
    "3-hydroxy-3-methylglutaryl-coenzyme A synthase activity" RELATED[ EC:2 ]
    "acetoacetyl coenzyme A transacetase activity" RELATED[ EC:2 ]
    "acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" RELATED[ EC:2 ]
    "beta-hydroxy-beta-methylglutaryl-CoA synthase activity" RELATED[ EC:2 ]
    "HMG-CoA synthase activity" RELATED[ EC:2 ]
    "hydroxymethylglutaryl coenzyme A synthase activity" RELATED[ EC:2 ]
    "hydroxymethylglutaryl coenzyme A-condensing enzyme" RELATED[ EC:2 ]
    "hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.3.3.10
KEGG_REACTION:R01978
MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
Reactome:R-HSA-191323 "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA"
Reactome:R-HSA-73918 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH"
RHEA:10188