FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term iduronate-2-sulfatase activity ID (Ontology) GO:0004423 (Gene Ontology)
Definition Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.[ EC:3 ]
Also Known As "iduronate-2-sulphatase activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 iduronate-2-sulfatase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | iduronate-2-sulfatase activity       1
Spanning Tree (Parents/Children)
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  hydrolase activity, acting on ester bonds
   |__sulfuric ester hydrolase activity
       |__iduronate-2-sulfatase activity  1 rec.
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Is a sulfuric ester hydrolase activity
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Synonyms
  • "2-sulfo-L-iduronate 2-sulfatase activity" RELATED[ EC:3 ]
    "chondroitinsulfatase" BROAD[ EC:3 ]
    "iduronate sulfatase activity" RELATED[ EC:3 ]
    "iduronate sulfate sulfatase activity" RELATED[ EC:3 ]
    "iduronate-2-sulfate sulfatase activity" RELATED[ EC:3 ]
    "iduronate-2-sulphatase activity" EXACT
    "iduronide-2-sulfate sulfatase activity" RELATED[ EC:3 ]
    "idurono-2-sulfatase activity" RELATED[ EC:3 ]
    "L-iduronate 2-sulfate sulfatase activity" RELATED[ EC:3 ]
    "L-iduronate-2-sulfate 2-sulfohydrolase activity" RELATED[ EC:3 ]
    "L-idurono sulfate sulfatase activity" RELATED[ EC:3 ]
    "L-iduronosulfatase activity" RELATED[ EC:3 ]
    "sulfo-L-iduronate sulfatase activity" RELATED[ EC:3 ]
    "sulfoiduronate sulfohydrolase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.1.6.13
MetaCyc:3.1.6.13-RXN
Reactome:R-HSA-1678650 "IDS hydrolyses Heparan sulfate chain(5)"
Reactome:R-HSA-1793182 "IDS hydrolyses dermatan sulfate (Chebi:63517 chain)"
Reactome:R-HSA-2262743 "Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain)"
Reactome:R-HSA-9036046 "Defective IDS does not hydrolyse Heparan sulfate chain(5)"