FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term 1-phosphatidylinositol 4-kinase activity ID (Ontology) GO:0004430 (Gene Ontology)
Definition Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+.[ EC:2 ]
Also Known As"phosphatidylinositol 4-kinase activity" ; "PI 4-kinase activity" ; "PI4-kinase activity" (for all, see Synonyms field below)
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 1-phosphatidylinositol 4-kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 1-phosphatidylinositol 4-kinase activity
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lipid kinase activity___________________________________
phosphotransferase activity, alcohol group as acceptor__|
                                                        phosphatidylinositol kinase activity
                                                         |__1-phosphatidylinositol 4-kinase activity  3 rec.
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Is a phosphatidylinositol kinase activity
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Synonyms
  • "phosphatidylinositol 4-kinase activity" EXACT[ EC:2 ]
    "phosphatidylinositol kinase (phosphorylating) activity" BROAD[ EC:2 ]
    "phosphatidylinositol kinase activity" BROAD[ EC:2 ]
    "PI 4-kinase activity" EXACT[ EC:2 ]
    "PI kinase activity" BROAD[ EC:2 ]
    "PI4-kinase activity" EXACT[ EC:2 ]
    "PI4K" EXACT[ EC:2 ]
    "PI4K-alpha activity" EXACT[ EC:2 ]
    "PtdIns-4-kinase activity" EXACT[ EC:2 ]
    "type II phosphatidylinositol kinase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.1.67
KEGG_REACTION:R03361
MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN
Reactome:R-HSA-1675780 "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane"
Reactome:R-HSA-1675813 "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane"
Reactome:R-HSA-1675883 "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane"
Reactome:R-HSA-1675974 "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane"
Reactome:R-HSA-1676185 "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane"
RHEA:19877