FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term phosphatidylinositol-4,5-bisphosphate phospholipase C activity ID (Ontology) GO:0004435 (Gene Ontology)
Definition Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+.
Also Known As "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity" ; "phosphatidylinositol-4,5-bisphosphate phospholipase C-type activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 phosphatidylinositol-4,5-bisphosphate phospholipase C activity (all annotations which use CV term, excluding "NOT" statements)
     enables | phosphatidylinositol-4,5-bisphosphate phospholipase C activity
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glycerophospholipase activity__________
phosphoric diester hydrolase activity__|
                                       C-type glycerophospholipase activity
                                        |__phosphatidylinositol-4,5-bisphosphate phospholipase C activity  3 rec.
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Is a C-type glycerophospholipase activity
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Synonyms
  • "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" RELATED[ EC:3 ]
    "1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" RELATED[ EC:3 ]
    "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity" EXACT
    "monophosphatidylinositol phosphodiesterase activity" BROAD[ EC:3 ]
    "phosphatidylinositol phospholipase C activity" BROAD
    "phosphatidylinositol-4,5-bisphosphate hydrolysis" RELATED
    "phosphatidylinositol-4,5-bisphosphate phospholipase C-type activity" EXACT
    "phosphoinositidase C activity" RELATED[ EC:3 ]
    "phosphoinositide phospholipase C activity" RELATED[ EC:3 ]
    "PI-PLC activity" RELATED[ EC:3 ]
    "triphosphoinositide phosphodiesterase activity" BROAD[ EC:3 ]
Secondary IDs
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EC:3.1.4.11
KEGG_REACTION:R03435
MetaCyc:3.1.4.11-RXN
Reactome:R-HSA-111879 "PIP2 hydrolysis"
Reactome:R-HSA-167686 "Active PLCG1 hydrolyses PIP2"
Reactome:R-HSA-1855177 "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane"
Reactome:R-HSA-1855214 "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane"
Reactome:R-HSA-1855221 "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane"
Reactome:R-HSA-202407 "PLC-gamma1 hydrolyses PIP2"
Reactome:R-HSA-2730847 "Hydrolysis of PIP2 by PLCG"
Reactome:R-HSA-5607735 "p-Y753,Y759-PLCG2 hydrolyses PIP2"
Reactome:R-HSA-622382 "PIP2 hydrolysis"
Reactome:R-HSA-9032478 "EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate"
Reactome:R-HSA-9717205 "GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG"
RHEA:33179