FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term isocitrate dehydrogenase (NADP+) activity ID (Ontology) GO:0004450 (Gene Ontology)
Definition Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.
Also Known As"isocitrate (NADP) dehydrogenase activity" ; "isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" ; "isocitrate dehydrogenase (NADP) activity" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 isocitrate dehydrogenase (NADP+) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | isocitrate dehydrogenase (NADP+) activity
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  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
   |__isocitrate dehydrogenase [NAD(P)+] activity
       |__isocitrate dehydrogenase (NADP+) activity  1 rec.
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Is a isocitrate dehydrogenase [NAD(P)+] activity
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Synonyms
  • "dual-cofactor-specific isocitrate dehydrogenase activity" RELATED[ EC:1 ]
    "isocitrate (NADP) dehydrogenase activity" EXACT[ EC:1 ]
    "isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT[ EC:1 ]
    "isocitrate dehydrogenase (NADP) activity" EXACT[ EC:1 ]
    "isocitrate dehydrogenase (NADP-dependent) activity" EXACT[ EC:1 ]
    "isocitrate:NADP+ oxidoreductase (decarboxylating)" EXACT[ EC:1 ]
    "NADP isocitric dehydrogenase activity" EXACT[ EC:1 ]
    "NADP(+)-ICDH activity" RELATED[ EC:1 ]
    "NADP(+)-IDH activity" RELATED[ EC:1 ]
    "NADP(+)-linked isocitrate dehydrogenase activity" EXACT[ EC:1 ]
    "NADP-dependent isocitrate dehydrogenase activity" EXACT[ EC:1 ]
    "NADP-dependent isocitric dehydrogenase activity" EXACT[ EC:1 ]
    "NADP-linked isocitrate dehydrogenase activity" EXACT[ EC:1 ]
    "NADP-specific isocitrate dehydrogenase activity" EXACT[ EC:1 ]
    "triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity" EXACT[ EC:1 ]
Secondary IDs
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EC:1.1.1.42
MetaCyc:ISOCITDEH-RXN
Reactome:R-HSA-389540 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+"
Reactome:R-HSA-389550 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+"
Reactome:R-HSA-450984 "IDH2 dimer decarboxylates isocitrate"
RHEA:19629