FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term lactoylglutathione lyase activity ID (Ontology) GO:0004462 (Gene Ontology)
Definition Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.[ EC:4 ]
Comment
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 lactoylglutathione lyase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | lactoylglutathione lyase activity       1
Spanning Tree (Parents/Children)
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  lyase activity
   |__carbon-sulfur lyase activity
       |__lactoylglutathione lyase activity  1 rec.
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Is a carbon-sulfur lyase activity
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Synonyms
  • "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity" RELATED[ EC:4 ]
    "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)" RELATED[ EC:4 ]
    "aldoketomutase activity" RELATED[ EC:4 ]
    "glyoxalase I activity" RELATED[ EC:4 ]
    "glyoxylase I" RELATED[ EC:4 ]
    "ketone-aldehyde mutase activity" RELATED[ EC:4 ]
    "methylglyoxalase activity" RELATED[ EC:4 ]
Secondary IDs
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EC:4.4.1.5
KEGG_REACTION:R02530
MetaCyc:GLYOXI-RXN
Reactome:R-HSA-5694071 "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH"
RHEA:19069