FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term lipoprotein lipase activity ID (Ontology) GO:0004465 (Gene Ontology)
Definition Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. May also hydrolyze diacylglycerol and phospholipids present in lipoproteins.[ EC:3 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 lipoprotein lipase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | lipoprotein lipase activity
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lipase activity______________________
carboxylic ester hydrolase activity__|
                                     triacylglycerol lipase activity
                                      |__lipoprotein lipase activity  1 rec.
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Is a triacylglycerol lipase activity
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Synonyms
  • "clearing factor lipase activity" RELATED[ EC:3 ]
    "diacylglycerol hydrolase activity" RELATED[ EC:3 ]
    "diacylglycerol lipase activity" RELATED[ EC:3 ]
    "diglyceride lipase activity" RELATED[ EC:3 ]
    "lipemia-clearing factor" RELATED[ EC:3 ]
    "postheparin esterase activity" RELATED[ EC:3 ]
    "postheparin lipase activity" RELATED[ EC:3 ]
    "triacylglycero-protein acylhydrolase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.1.1.34
Reactome:R-HSA-1482811 "DAG is hydrolyzed to 2-MAG by PNPLA2/3"
Reactome:R-HSA-174757 "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols"
Reactome:R-HSA-2395768 "LPL hydrolyses TGs from mature CMs"
Reactome:R-HSA-6789310 "LIPs hydrolyse TG to DAG and RCOOH"
Reactome:R-HSA-8979996 "LIPs hydrolyze TG to DAG and LCFA"
Reactome:R-HSA-8980228 "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA"