FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term long-chain fatty acid-CoA ligase activity ID (Ontology) GO:0004467 (Gene Ontology)
Definition Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
Also Known As "long-chain acyl-CoA synthetase activity" ; "long-chain-fatty-acid-CoA ligase activity" ; "long-chain-fatty-acyl-CoA synthetase activity"
Comment
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 long-chain fatty acid-CoA ligase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | long-chain fatty acid-CoA ligase activity
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fatty acid ligase activity__
CoA-ligase activity_________|
                            fatty acid-CoA ligase activity
                             |__long-chain fatty acid-CoA ligase activity  21 rec.
                                 |__arachidonate-CoA ligase activity
                                 |__myristoyl-CoA ligase activity
                                 |__oleoyl-CoA ligase activity
                                 |__palmitoyl-CoA ligase activity 1 rec.
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Is a fatty acid-CoA ligase activity
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Synonyms
  • "acyl-activating enzyme activity" BROAD
    "acyl-CoA ligase activity" RELATED
    "acyl-CoA synthetase activity" RELATED[ EC:6 ]
    "fatty acid thiokinase (long-chain) activity" RELATED
    "LCFA synthetase activity" RELATED
    "lignoceroyl-CoA synthase activity" RELATED
    "long chain fatty acyl-CoA synthetase activity" RELATED
    "long-chain acyl CoA synthetase activity" RELATED
    "long-chain acyl-CoA synthetase activity" EXACT
    "long-chain acyl-coenzyme A synthetase activity" RELATED
    "long-chain fatty acid activation" RELATED
    "long-chain fatty acyl coenzyme A synthetase activity" RELATED
    "long-chain-fatty-acid-CoA ligase activity" EXACT
    "long-chain-fatty-acyl-CoA synthetase activity" EXACT
    "pristanoyl-CoA synthetase" NARROW
    "stearoyl-CoA synthetase" NARROW
    "thiokinase" RELATED
Secondary IDs
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EC:6.2.1.3
MetaCyc:RXN-7904
Reactome:R-HSA-159425 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)"
Reactome:R-HSA-192137 "THCA is conjugated with Coenzyme A (SLC27A5 BACS)"
Reactome:R-HSA-193401 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)"
Reactome:R-HSA-193407 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)"
Reactome:R-HSA-193424 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)"
Reactome:R-HSA-193711 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)"
Reactome:R-HSA-193727 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)"
Reactome:R-HSA-193743 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)"
Reactome:R-HSA-193766 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)"
Reactome:R-HSA-201035 "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA"
Reactome:R-HSA-2046085 "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA"
Reactome:R-HSA-2046098 "Activation of linoleic acid to linoleoyl-CoA"
Reactome:R-HSA-548843 "ACSL3,4 ligate CoA to AA to form AA-CoA"
Reactome:R-HSA-5696004 "ACSF2 ligates CoA-SH to MCFA"
Reactome:R-HSA-9734535 "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA"
RHEA:15421
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