FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term malate dehydrogenase (decarboxylating) (NADP+) activity ID (Ontology) GO:0004473 (Gene Ontology)
Definition Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 malate dehydrogenase (decarboxylating) (NADP+) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | malate dehydrogenase (decarboxylating) (NADP+) activity
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oxidoreductase activity, acting on CH-OH group of donors
 |__oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor__
malate dehydrogenase activity                                                              |
 |__malic enzyme activity__________________________________________________________________|
                                                                                         malate dehydrogenase (decarboxylating) (NADP+) activity  5 rec.
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Is a malic enzyme activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Part of
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Synonyms
  • "'malic' enzyme" RELATED[ EC:1 ]
    "(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" RELATED[ EC:1 ]
    "L-malate:NADP oxidoreductase activity" RELATED[ EC:1 ]
    "malate dehydrogenase (decarboxylating, NADP)" RELATED[ EC:1 ]
    "malate dehydrogenase (NADP, decarboxylating)" RELATED[ EC:1 ]
    "NADP-linked decarboxylating malic enzyme" RELATED[ EC:1 ]
    "NADP-malic enzyme activity" RELATED[ EC:1 ]
    "NADP-specific malate dehydrogenase activity" RELATED[ EC:1 ]
    "NADP-specific malic enzyme" RELATED[ EC:1 ]
Secondary IDs
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EC:1.1.1.40
KEGG_REACTION:R00216
MetaCyc:MALIC-NADP-RXN
Reactome:R-HSA-9012036 "ME1 tetramer decarboxylates MAL to PYR"
Reactome:R-HSA-9012349 "ME3 tetramer decarboxylates MAL to PYR"
RHEA:18253