FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term mannose-6-phosphate isomerase activity ID (Ontology) GO:0004476 (Gene Ontology)
Definition Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 mannose-6-phosphate isomerase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | mannose-6-phosphate isomerase activity
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  intramolecular oxidoreductase activity
   |__intramolecular oxidoreductase activity, interconverting aldoses and ketoses
       |__mannose-6-phosphate isomerase activity  1 rec.
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Is a intramolecular oxidoreductase activity, interconverting aldoses and ketoses
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Synonyms
  • "D-mannose-6-phosphate aldose-ketose-isomerase activity" RELATED[ EC:5 ]
    "D-mannose-6-phosphate ketol-isomerase activity" RELATED[ EC:5 ]
    "mannose phosphate isomerase activity" RELATED[ EC:5 ]
    "phosphohexoisomerase activity" BROAD[ EC:5 ]
    "phosphohexomutase activity" BROAD[ EC:5 ]
    "phosphomannoisomerase activity" RELATED[ EC:5 ]
    "phosphomannose isomerase activity" RELATED[ EC:5 ]
Secondary IDs
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EC:5.3.1.8
MetaCyc:MANNPISOM-RXN
Reactome:R-HSA-3781832 "Defective MPI does not isomerize Fru6P to Man6P"
Reactome:R-HSA-532549 "MPI isomerises Fru6P to Man6P"
RHEA:12356