FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term methenyltetrahydrofolate cyclohydrolase activity ID (Ontology) GO:0004477 (Gene Ontology)
Definition Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.[ EC:3 ]
Also Known As "5,10-methenyl-THF cyclohydrolase activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 Genes
 methenyltetrahydrofolate cyclohydrolase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | methenyltetrahydrofolate cyclohydrolase activity       2
Spanning Tree (Parents/Children)
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  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
   |__cyclohydrolase activity
       |__methenyltetrahydrofolate cyclohydrolase activity  2 rec.
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Is a cyclohydrolase activity
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Synonyms
  • "5,10-methenyl-THF cyclohydrolase activity" EXACT
    "5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)" RELATED[ EC:3 ]
    "citrovorum factor cyclodehydrase activity" RELATED[ EC:3 ]
    "formyl-methenyl-methylenetetrahydrofolate synthetase (combined)" RELATED[ EC:3 ]
Secondary IDs
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EC:3.5.4.9
MetaCyc:METHENYLTHFCYCLOHYDRO-RXN
Reactome:R-HSA-200661 "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG"
Reactome:R-HSA-200740 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate"
Reactome:R-HSA-6801328 "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF"
RHEA:23700