FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term methionine adenosyltransferase activity ID (Ontology) GO:0004478 (Gene Ontology)
Definition Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.[ EC:2 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 methionine adenosyltransferase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | methionine adenosyltransferase activity       1
Spanning Tree (Parents/Children)
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  transferase activity
   |__transferase activity, transferring alkyl or aryl (other than methyl) groups
       |__methionine adenosyltransferase activity  1 rec.
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Is a transferase activity, transferring alkyl or aryl (other than methyl) groups
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Synonyms
  • "adenosylmethionine synthetase activity" RELATED[ EC:2 ]
    "AdoMet synthetase activity" RELATED[ EC:2 ]
    "ATP-methionine adenosyltransferase activity" RELATED[ EC:2 ]
    "ATP:L-methionine S-adenosyltransferase activity" RELATED[ EC:2 ]
    "methionine S-adenosyltransferase activity" RELATED[ EC:2 ]
    "methionine-activating enzyme" RELATED[ EC:2 ]
    "S-adenosyl-L-methionine synthetase activity" RELATED[ EC:2 ]
    "S-adenosylmethionine synthase activity" RELATED[ EC:2 ]
    "S-adenosylmethionine synthetase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.5.1.6
MetaCyc:S-ADENMETSYN-RXN
Reactome:R-HSA-174391 "MAT1A multimers transfer Ado from ATP to L-Met"
Reactome:R-HSA-5603087 "Defective MAT1A does not transfer Ado from ATP to L-Met"
Reactome:R-HSA-5603114 "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met"
RHEA:21080