FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term mRNA 5'-cap (guanine-N7-)-methyltransferase activity ID (Ontology) GO:0004482 (Gene Ontology)
Definition Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.[ EC:2 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 mRNA 5'-cap (guanine-N7-)-methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | mRNA 5'-cap (guanine-N7-)-methyltransferase activity
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methyltransferase activity
 |__N-methyltransferase activity___________________________
RNA methyltransferase activity                             |
 |__mRNA methyltransferase activity________________________|
S-adenosylmethionine-dependent methyltransferase activity  |
 |__mRNA methyltransferase activity________________________|
                                                           mRNA 5'-cap (guanine-N7-)-methyltransferase activity  1 rec.
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Is a N-methyltransferase activity
mRNA methyltransferase activity
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Synonyms
  • "guanine-7-methyltransferase activity" RELATED[ EC:2 ]
    "messenger ribonucleate guanine 7-methyltransferase activity" RELATED[ EC:2 ]
    "messenger RNA guanine 7-methyltransferase activity" RELATED[ EC:2 ]
    "S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity" RELATED[ EC:2 ]
    "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.1.1.56
MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN
Reactome:R-HSA-77090 "Methylation of GMP-cap by RNA Methyltransferase"
Reactome:R-HSA-9684016 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs"
Reactome:R-HSA-9684017 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)"
Reactome:R-HSA-9684018 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)"
Reactome:R-HSA-9694476 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs"
Reactome:R-HSA-9694492 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)"
Reactome:R-HSA-9694737 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand)"
Reactome:R-HSA-9830848 "L protein acts as a cap N7 methyltransferase to modify RSV mRNAs"
Reactome:R-HSA-9923104 "NS5 acts as a cap N7 methyltransferase to methylate 5 G pppA of DENV genomic +ssRNA"