FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term methyltransferase cap1 activity ID (Ontology) GO:0004483 (Gene Ontology)
Definition Catalysis of the reaction: a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA or snRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA or snRNA + S-adenosyl-L-homocysteine + H+. This activity catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNAs and snRNAs.[ EC:2 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 methyltransferase cap1 activity (all annotations which use CV term, excluding "NOT" statements)
     enables | methyltransferase cap1 activity
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methyltransferase activity
 |__O-methyltransferase activity____
 |__RNA methyltransferase activity__|
catalytic activity, acting on RNA   |
 |__RNA methyltransferase activity__|
                                    methyltransferase cap1 activity  2 rec.
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Is a O-methyltransferase activity
RNA methyltransferase activity
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Synonyms
  • "messenger ribonucleate nucleoside 2'-methyltransferase activity" RELATED[ EC:2 ]
    "messenger RNA (nucleoside-2'-)-methyltransferase activity" RELATED[ EC:2 ]
    "mRNA (adenosine-2'-O-)-methyltransferase activity" RELATED[ EC:2 ]
    "mRNA (nucleoside-2'-O-)-methyltransferase activity" RELATED[ EC:2 ]
    "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.1.1.57
MetaCyc:2.1.1.57-RXN
Reactome:R-HSA-9684030 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)"
Reactome:R-HSA-9684032 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)"
Reactome:R-HSA-9684033 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs"
Reactome:R-HSA-9694499 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs"
Reactome:R-HSA-9694521 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)"
Reactome:R-HSA-9694721 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)"
Reactome:R-HSA-9834003 "L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs"
Reactome:R-HSA-9923097 "NS5 acts as a cap 2'-O-methyltransferase to methylate 5 m7GpppA of DENV genomic +ssRNA"
RHEA:19617
RHEA:60860
RHEA:60864
RHEA:67020