FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term mRNA guanylyltransferase activity ID (Ontology) GO:0004484 (Gene Ontology)
Definition Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue.[ EC:2 ]
Also Known As"GTP:mRNA guanylyltransferase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 mRNA guanylyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | mRNA guanylyltransferase activity
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guanylyltransferase activity_______
catalytic activity, acting on RNA__|
                                   RNA guanylyltransferase activity
                                    |__mRNA guanylyltransferase activity  1 rec.
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Is a RNA guanylyltransferase activity
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Synonyms
  • "GTP--RNA guanylyltransferase activity" RELATED[ EC:2 ]
    "GTP:mRNA guanylyltransferase activity" EXACT
    "messenger RNA guanylyltransferase activity" RELATED[ EC:2 ]
    "mRNA capping enzyme activity" RELATED[ EC:2 ]
    "protein lambda2" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.7.50
MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN
Reactome:R-HSA-77081 "Formation of the CE:GMP intermediate complex"
Reactome:R-HSA-77083 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA"
Reactome:R-HSA-9815529 "nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs"
Reactome:R-HSA-9923071 "NS5 transfers guanylyl onto DENV genomic 5'-ppRNA"
RHEA:54592
RHEA:60836
RHEA:60844