FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term methylcrotonoyl-CoA carboxylase activity ID (Ontology) GO:0004485 (Gene Ontology)
Definition Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate.[ EC:6 ]
Also Known As"MCCC activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 methylcrotonoyl-CoA carboxylase activity (all annotations which use CV term, excluding "NOT" statements)
     contributes_to | methylcrotonoyl-CoA carboxylase activity       --
     enables | methylcrotonoyl-CoA carboxylase activity       --
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  ligase activity, forming carbon-carbon bonds
   |__CoA carboxylase activity
       |__methylcrotonoyl-CoA carboxylase activity  3 rec.
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Is a CoA carboxylase activity
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Synonyms
  • "3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)" RELATED[ EC:6 ]
    "beta-methylcrotonyl CoA carboxylase activity" RELATED[ EC:6 ]
    "beta-methylcrotonyl coenzyme A carboxylase activity" RELATED[ EC:6 ]
    "beta-methylcrotonyl-CoA carboxylase activity" RELATED[ EC:6 ]
    "MCCC activity" EXACT
    "methylcrotonyl coenzyme A carboxylase activity" RELATED[ EC:6 ]
    "methylcrotonyl-CoA carboxylase activity" RELATED[ EC:6 ]
Secondary IDs
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EC:6.4.1.4
KEGG_REACTION:R04138
MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN
Reactome:R-HSA-508308 "beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + HCO3- (MCCA)"
Reactome:R-HSA-70773 "beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA)"
Reactome:R-HSA-9909466 "MCCC mutants don't synthesize beta-methylglutaconyl-CoA"
RHEA:13589