FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term methylenetetrahydrofolate dehydrogenase (NAD+) activity ID (Ontology) GO:0004487 (Gene Ontology)
Definition Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH.
Comment
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 methylenetetrahydrofolate dehydrogenase (NAD+) activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | methylenetetrahydrofolate dehydrogenase (NAD+) activity       1
Spanning Tree (Parents/Children)
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  oxidoreductase activity, acting on the CH-NH group of donors
   |__oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
       |__methylenetetrahydrofolate dehydrogenase (NAD+) activity  1 rec.
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Is a oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
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Synonyms
  • "5,10-methylenetetrahydrofolate dehydrogenase activity" RELATED[ EC:1 ]
    "5,10-methylenetetrahydrofolate:NAD+ oxidoreductase" RELATED[ EC:1 ]
Secondary IDs
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EC:1.5.1.15
KEGG_REACTION:R01218
MetaCyc:1.5.1.15-RXN
Reactome:R-HSA-6801462 "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF"
RHEA:22892