FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

methylenetetrahydrofolate dehydrogenase (NAD+) activity

ID (Ontology)

GO:0004487 (Gene Ontology)

Definition

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH.

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
methylenetetrahydrofolate dehydrogenase (NAD+) activity (all annotations which use CV term, excluding "NOT" statements)
enables \| methylenetetrahydrofolate dehydrogenase (NAD+) activity

Spanning Tree (Parents/Children)

  oxidoreductase activity, acting on the CH-NH group of donors
   |__oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
       |__methylenetetrahydrofolate dehydrogenase (NAD+) activity  1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Part of
Synonyms & Secondary IDs
Synonyms
	"5,10-methylenetetrahydrofolate dehydrogenase activity" RELATED[ EC:1 ] "5,10-methylenetetrahydrofolate:NAD+ oxidoreductase" RELATED[ EC:1 ]
Secondary IDs

External Crossreferences & Linkouts
	EC:1.5.1.15 KEGG_REACTION:R01218 MetaCyc:1.5.1.15-RXN Reactome:R-HSA-6801462 "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF" RHEA:22892