FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term methylenetetrahydrofolate dehydrogenase (NADP+) activity ID (Ontology) GO:0004488 (Gene Ontology)
Definition Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH.[ EC:1 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 Genes
 methylenetetrahydrofolate dehydrogenase (NADP+) activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | methylenetetrahydrofolate dehydrogenase (NADP+) activity       2
Spanning Tree (Parents/Children)
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  oxidoreductase activity, acting on the CH-NH group of donors
   |__oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
       |__methylenetetrahydrofolate dehydrogenase (NADP+) activity  2 rec.
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Is a oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
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Synonyms
  • "5,10-methylenetetrahydrofolate:NADP oxidoreductase activity" RELATED[ EC:1 ]
    "5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.5.1.5
KEGG_REACTION:R01220
MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN
Reactome:R-HSA-200644 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+"
Reactome:R-HSA-200718 "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG"
RHEA:22812