FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term methylglutaconyl-CoA hydratase activity ID (Ontology) GO:0004490 (Gene Ontology)
Definition Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O.[ EC:4 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 methylglutaconyl-CoA hydratase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | methylglutaconyl-CoA hydratase activity
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  carbon-oxygen lyase activity
   |__hydro-lyase activity
       |__methylglutaconyl-CoA hydratase activity  1 rec.
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Is a hydro-lyase activity
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Synonyms
  • "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)" RELATED[ EC:4 ]
    "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity" RELATED[ EC:4 ]
    "3-methylglutaconyl CoA hydratase activity" RELATED[ EC:4 ]
    "methylglutaconase activity" RELATED[ EC:4 ]
    "methylglutaconyl coenzyme A hydratase activity" RELATED[ EC:4 ]
Secondary IDs
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EC:4.2.1.18
KEGG_REACTION:R02085
MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN
Reactome:R-HSA-70785 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA"
Reactome:R-HSA-9914271 "AUH mutants don't synthesize 3-hydroxy-methylglutaryl-CoA"
RHEA:21536