FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

methylmalonate-semialdehyde dehydrogenase (acylating, NAD+) activity

ID (Ontology)

GO:0004491 (Gene Ontology)

Definition

Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + hydrogencarbonate + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.[ EC:1 PubMed:2768248 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
methylmalonate-semialdehyde dehydrogenase (acylating, NAD+) activity (all annotations which use CV term, excluding "NOT" statements)
enables \| methylmalonate-semialdehyde dehydrogenase (acylating, NAD+) activity

Spanning Tree (Parents/Children)

  oxidoreductase activity, acting on the aldehyde or oxo group of donors
   |__oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
       |__methylmalonate-semialdehyde dehydrogenase (acylating, NAD+) activity  1 rec.

Spanning Tree View Settings
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Relationships
Is a	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Part of
Synonyms & Secondary IDs
Synonyms
	"methylmalonate-semialdehyde dehydrogenase (acylating) activity" RELATED "MMSA dehydrogenase activity" RELATED[ EC:1 ] "MSDH activity" RELATED[ EC:1 ]
Secondary IDs

External Crossreferences & Linkouts
	EC:1.2.1.27 MetaCyc:1.2.1.27-RXN Reactome:R-HSA-70893 "methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+" RHEA:20804 RHEA:76615 RHEA:76623 RHEA:76627