FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity ID (Ontology) GO:0004491 (Gene Ontology)
Definition Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + hydrogencarbonate + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.[ EC:1 PubMed:2768248 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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Relevant FlyBase reports
 Genes
 methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity       1
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  oxidoreductase activity, acting on the aldehyde or oxo group of donors
   |__oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
       |__methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity  1 rec.
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Is a oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
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Synonyms
  • "methylmalonate-semialdehyde dehydrogenase (acylating) activity" RELATED
    "MMSA dehydrogenase activity" RELATED[ EC:1 ]
    "MSDH activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.2.1.27
MetaCyc:1.2.1.27-RXN
Reactome:R-HSA-70893 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+"
RHEA:20804
RHEA:76615