FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term N,N-dimethylaniline monooxygenase activity ID (Ontology) GO:0004499 (Gene Ontology)
Definition Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
Also Known As"dimethylaniline monooxygenase (N-oxide-forming) activity" ; "methylphenyltetrahydropyridine N-monooxygenase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 N,N-dimethylaniline monooxygenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | N,N-dimethylaniline monooxygenase activity
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monooxygenase activity_________________________________________________________________________________
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen__|
                                                                                         oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
                                                                                          |__N,N-dimethylaniline monooxygenase activity  2 rec.
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Is a oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
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Synonyms
  • "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity" RELATED[ EC:1 ]
    "dimethylaniline monooxygenase (N-oxide-forming) activity" EXACT
    "dimethylaniline N-oxidase activity" RELATED[ EC:1 ]
    "dimethylaniline oxidase activity" RELATED[ EC:1 ]
    "DMA oxidase activity" RELATED[ EC:1 ]
    "FAD-containing monooxygenase activity" RELATED[ EC:1 ]
    "flavin mixed function oxidase activity" RELATED[ EC:1 ]
    "flavin monooxygenase activity" RELATED[ EC:1 ]
    "flavin-containing monooxygenase activity" BROAD[ EC:1 ]
    "FMO activity" RELATED[ EC:1 ]
    "methylphenyltetrahydropyridine N-monooxygenase activity" EXACT
    "mixed-function amine oxidase activity" RELATED[ EC:1 ]
    "N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)" RELATED[ EC:1 ]
    "Ziegler's enzyme" RELATED[ EC:1 ]
Secondary IDs
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MetaCyc:1.14.13.8-RXN
Reactome:R-HSA-139970 "FMO3:FAD N-oxidises TMA to TMAO"
Reactome:R-HSA-217255 "FMO1:FAD N-oxidises TAM"
Reactome:R-HSA-5602966 "Defective FMO3 does not N-oxidise TMA"
RHEA:24468