FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term phenylalanine 4-monooxygenase activity ID (Ontology) GO:0004505 (Gene Ontology)
Definition Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.[ PubMed:4004813 ]
Also Known As "phenylalanine hydroxylase activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 Genes
 phenylalanine 4-monooxygenase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | phenylalanine 4-monooxygenase activity       2
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monooxygenase activity_________________________________________________________________________________
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen__|
                                                                                         oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
                                                                                          |__phenylalanine 4-monooxygenase activity  2 rec.
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Is a oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
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Synonyms
  • "L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" RELATED[ EC:1 ]
    "PAH activity" RELATED[ EC:1 ]
    "phenylalaninase activity" RELATED[ EC:1 ]
    "phenylalanine 4-hydroxylase activity" RELATED[ EC:1 ]
    "phenylalanine hydroxylase activity" EXACT
Secondary IDs
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EC:1.14.16.1
MetaCyc:RXN66-569
Reactome:R-HSA-5649483 "Defective PAH does not hydroxylate L-Phe to L-Tyr"
Reactome:R-HSA-71118 "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr"
RHEA:20273