FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term tryptophan 5-monooxygenase activity ID (Ontology) GO:0004510 (Gene Ontology)
Definition Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O.[ EC:1 ]
Also Known As"L-tryptophan hydroxylase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 tryptophan 5-monooxygenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | tryptophan 5-monooxygenase activity
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monooxygenase activity_________________________________________________________________________________
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen__|
                                                                                         oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
                                                                                          |__tryptophan 5-monooxygenase activity  2 rec.
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Is a oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
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Synonyms
  • "indoleacetic acid-5-hydroxylase activity" RELATED[ EC:1 ]
    "L-tryptophan hydroxylase activity" EXACT
    "L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)" RELATED[ EC:1 ]
    "tryptophan 5-hydroxylase activity" RELATED[ EC:1 ]
    "tryptophan hydroxylase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.14.16.4
MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN
Reactome:R-HSA-209828 "Tryptophan is hydroxylated"
RHEA:16709