FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term inositol-3-phosphate synthase activity ID (Ontology) GO:0004512 (Gene Ontology)
Definition Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.[ EC:5 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 inositol-3-phosphate synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | inositol-3-phosphate synthase activity
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  isomerase activity
   |__intramolecular lyase activity
       |__inositol-3-phosphate synthase activity  1 rec.
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Is a intramolecular lyase activity
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Synonyms
  • "1L-myo-inositol-1-phosphate lyase (isomerizing)" RELATED[ EC:5 ]
    "D-glucose 6-phosphate cycloaldolase activity" RELATED[ EC:5 ]
    "glucocycloaldolase activity" RELATED[ EC:5 ]
    "glucose 6-phosphate cyclase activity" RELATED[ EC:5 ]
    "glucose-6-phosphate inositol monophosphate cycloaldolase activity" RELATED[ EC:5 ]
    "inositol 1-phosphate synthatase activity" RELATED[ EC:5 ]
    "inositol 1-phosphate synthetase activity" RELATED[ EC:5 ]
Secondary IDs
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EC:5.5.1.4
KEGG_REACTION:R07324
MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN
Reactome:R-HSA-1855178 "Glc6P is isomerised to I3P by ISYNA1 in the cytosol"
RHEA:10716