FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
Help Close All Open All
General Information
Term inositol-3-phosphate synthase activity ID (Ontology) GO:0004512 (Gene Ontology)
Definition Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.[ EC:5 ]
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 inositol-3-phosphate synthase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | inositol-3-phosphate synthase activity       1
Spanning Tree (Parents/Children)
Only view relationship: 
  isomerase activity
   |__intramolecular lyase activity
       |__inositol-3-phosphate synthase activity  1 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a intramolecular lyase activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "1L-myo-inositol-1-phosphate lyase (isomerizing)" RELATED[ EC:5 ]
    "D-glucose 6-phosphate cycloaldolase activity" RELATED[ EC:5 ]
    "glucocycloaldolase activity" RELATED[ EC:5 ]
    "glucose 6-phosphate cyclase activity" RELATED[ EC:5 ]
    "glucose-6-phosphate inositol monophosphate cycloaldolase activity" RELATED[ EC:5 ]
    "inositol 1-phosphate synthatase activity" RELATED[ EC:5 ]
    "inositol 1-phosphate synthetase activity" RELATED[ EC:5 ]
Secondary IDs
hide External Crossreferences & Linkouts
EC:5.5.1.4
KEGG_REACTION:R07324
MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN
Reactome:R-HSA-1855178 "Glc6P is isomerised to I3P by ISYNA1 in the cytosol"
RHEA:10716