FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term nitric-oxide synthase activity ID (Ontology) GO:0004517 (Gene Ontology)
Definition Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.[ EC:1 ]
Also Known As "nitric oxide synthase activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 nitric-oxide synthase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | nitric-oxide synthase activity       1
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monooxygenase activity_________________________________________________________________________________
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen__|
                                                                                         oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
                                                                                          |__nitric-oxide synthase activity  1 rec.
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Is a oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
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Synonyms
  • "endothelium-derived relaxation factor-forming enzyme activity" RELATED[ EC:1 ]
    "endothelium-derived relaxing factor synthase activity" RELATED[ EC:1 ]
    "L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity" RELATED[ EC:1 ]
    "NADPH-diaphorase activity" RELATED[ EC:1 ]
    "nitric oxide synthase activity" EXACT
    "nitric oxide synthetase activity" RELATED[ EC:1 ]
    "nitric-oxide synthetase activity" RELATED[ EC:1 ]
    "NO synthase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.14.13.39
MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN
Reactome:R-HSA-202127 "eNOS synthesizes NO"
Reactome:R-HSA-418436 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)"
RHEA:19897