FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term endonuclease activity ID (Ontology) GO:0004519 (Gene Ontology)
Definition Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.[ ISBN:0198547684 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 endonuclease activity (all annotations which use CV term, excluding "NOT" statements)
     enables | endonuclease activity
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  catalytic activity, acting on a nucleic acid
   |__nuclease activity
       |__endonuclease activity  101 rec.
           |__DNA endonuclease activity 49 rec.
           |   |__deoxyribonuclease (pyrimidine dimer) activity
           |   |__DNA endonuclease activity, producing 3'-phosphomonoesters(+) 5 rec.
           |   |__DNA endonuclease activity, producing 5'-phosphomonoesters(+) 13 rec.
           |   |__DNA-(apurinic or apyrimidinic site) endonuclease activity(+) 10 rec.
           |   |__double-stranded DNA endonuclease activity(+) 13 rec.
           |   |__excinuclease ABC activity
           |   |__flap endonuclease activity(+) 8 rec.
           |   |__restriction endodeoxyribonuclease activity(+)
           |   |__retroviral 3' processing activity
           |   |__single-stranded DNA endonuclease activity(+) 17 rec.
           |   |__T/G mismatch-specific endonuclease activity
           |__RNA endonuclease activity 69 rec.
               |__Enterobacter ribonuclease activity
               |__ribonuclease A activity
               |__ribonuclease MRP activity 2 rec.
               |__ribonuclease T1 activity
               |__ribonuclease T2 activity 2 rec.
               |__ribonuclease U2 activity
               |__RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism(+)
               |__RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism(+) 23 rec.
               |__rRNA endonuclease activity
               |__tRNA-intron lyase activity 3 rec.
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Reactome:R-HSA-5358512 "MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more"
Reactome:R-HSA-5358518 "MLH1:PMS2 makes single strand incision near 1-2 base mismatch"
Reactome:R-HSA-5690990 "5'- incision of DNA by ERCC1:ERCC4 in GG-NER"
Reactome:R-HSA-5693533 "DCLRE1C (ARTEMIS) processes DNA DSB ends"
Reactome:R-HSA-72180 "Cleavage of mRNA at the 3'-end"
Reactome:R-HSA-9970193 "CPSF3 cleaves pre-mRNA at distal 3'UTR PAS"
Reactome:R-HSA-9970282 "U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS"
Reactome:R-HSA-9970294 "CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS"