FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term DNA endonuclease activity ID (Ontology) GO:0004520 (Gene Ontology)
Definition Catalysis of the cleavage of ester linkages within deoxyribonucleic acid by creating internal breaks.[ ISBN:0198547684 ]
Also Known As "endodeoxyribonuclease activity"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      23
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 DNA endonuclease activity (all annotations which use CV term, excluding "NOT" statements)       2     23
     enables | DNA endonuclease activity       --      22
Spanning Tree (Parents/Children)
Only view relationship: 
nuclease activity
 |__endonuclease activity__________
 |__DNA nuclease activity__________|
catalytic activity, acting on DNA  |
 |__DNA nuclease activity__________|
                                   DNA endonuclease activity  47 rec.
                                    |__deoxyribonuclease (pyrimidine dimer) activity
                                    |__DNA endonuclease activity, producing 3'-phosphomonoesters 5 rec.
                                    |   |__3'-flap endonuclease activity 1 rec.
                                    |   |__crossover junction DNA endonuclease activity 4 rec.
                                    |   |__deoxyribonuclease II activity 1 rec.
                                    |__DNA endonuclease activity, producing 5'-phosphomonoesters 13 rec.
                                    |   |__5'-flap endonuclease activity 6 rec.
                                    |   |__CC-preferring endodeoxyribonuclease activity
                                    |   |__class II DNA-(apurinic or apyrimidinic site) endonuclease activity 4 rec.
                                    |   |__deoxyribonuclease I activity 3 rec.
                                    |   |__deoxyribonuclease IV (phage-T4-induced) activity
                                    |   |__deoxyribonuclease V activity
                                    |   |__type I site-specific deoxyribonuclease activity
                                    |   |__type II site-specific deoxyribonuclease activity
                                    |   |__type III site-specific deoxyribonuclease activity
                                    |__DNA-(apurinic or apyrimidinic site) endonuclease activity 10 rec.
                                    |   |__class I DNA-(apurinic or apyrimidinic site) endonuclease activity 6 rec.
                                    |   |__class II DNA-(apurinic or apyrimidinic site) endonuclease activity 4 rec.
                                    |__double-stranded DNA endonuclease activity
                                    |   |__ds/ssDNA junction-specific dsDNA endonuclease activity
                                    |__excinuclease ABC activity
                                    |__flap endonuclease activity 8 rec.
                                    |   |__3'-flap endonuclease activity 1 rec.
                                    |   |__5'-flap endonuclease activity 6 rec.
                                    |__restriction endodeoxyribonuclease activity
                                    |   |__type I site-specific deoxyribonuclease activity
                                    |   |__type II site-specific deoxyribonuclease activity
                                    |   |__type III site-specific deoxyribonuclease activity
                                    |   |__type IV site-specific deoxyribonuclease activity
                                    |__retroviral 3' processing activity
                                    |__single-stranded DNA endodeoxyribonuclease activity 4 rec.
                                    |   |__3' overhang single-stranded DNA endodeoxyribonuclease activity 1 rec.
                                    |   |__5' overhang single-stranded DNA endodeoxyribonuclease activity
                                    |__T/G mismatch-specific endonuclease activity
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Is a endonuclease activity
DNA nuclease activity
Part of
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Synonyms
  • "DNA nicking activity" RELATED
    "endodeoxyribonuclease activity" EXACT
    "endonuclease G activity" RELATED
Secondary IDs
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Reactome:R-HSA-110359 "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site"
Reactome:R-HSA-5686440 "MUS81:EME1,EME2 cleaves D-loop"
Reactome:R-HSA-5686657 "ERCC1:XPF cleaves flaps generated by SSA"
Reactome:R-HSA-5687464 "MRN and RBBP8 resect DNA DSBs in MMEJ"
Reactome:R-HSA-5690988 "3'-incision of DNA by ERCC5 (XPG) in GG-NER"
Reactome:R-HSA-5693584 "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)"
Reactome:R-HSA-5693608 "Initial resection of double-strand break ends"
Reactome:R-HSA-6782204 "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER"
Reactome:R-HSA-6782224 "3' incision by ERCC5 (XPG) in TC-NER"
Reactome:R-HSA-9023941 "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11"