FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term DNA endonuclease activity ID (Ontology) GO:0004520 (Gene Ontology)
Definition Catalysis of the cleavage of ester linkages within deoxyribonucleic acid by creating internal breaks.[ ISBN:0198547684 ]
Also Known As"endodeoxyribonuclease activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Gene Groups Genes
 DNA endonuclease activity (all annotations which use CV term, excluding "NOT" statements)
     contributes_to | DNA endonuclease activity       --
     enables | DNA endonuclease activity       --
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Vocabulary search 
nuclease activity
 |__endonuclease activity__________
 |__DNA nuclease activity__________|
catalytic activity, acting on DNA  |
 |__DNA nuclease activity__________|
                                   DNA endonuclease activity  49 rec.
                                    |__deoxyribonuclease (pyrimidine dimer) activity
                                    |__DNA endonuclease activity, producing 3'-phosphomonoesters 5 rec.
                                    |   |__3'-flap endonuclease activity 1 rec.
                                    |   |__crossover junction DNA endonuclease activity 4 rec.
                                    |   |__deoxyribonuclease II activity 1 rec.
                                    |__DNA endonuclease activity, producing 5'-phosphomonoesters 13 rec.
                                    |   |__5'-flap endonuclease activity 6 rec.
                                    |   |__CC-preferring endodeoxyribonuclease activity
                                    |   |__class II DNA-(apurinic or apyrimidinic site) endonuclease activity 4 rec.
                                    |   |__deoxyribonuclease I activity 3 rec.
                                    |   |__deoxyribonuclease IV (phage-T4-induced) activity
                                    |   |__deoxyribonuclease V activity
                                    |   |__type I site-specific deoxyribonuclease activity
                                    |   |__type II site-specific deoxyribonuclease activity
                                    |   |__type III site-specific deoxyribonuclease activity
                                    |__DNA-(apurinic or apyrimidinic site) endonuclease activity 10 rec.
                                    |   |__class I DNA-(apurinic or apyrimidinic site) endonuclease activity 6 rec.
                                    |   |__class II DNA-(apurinic or apyrimidinic site) endonuclease activity 4 rec.
                                    |__double-stranded DNA endonuclease activity 13 rec.
                                    |   |__ds/ssDNA junction-specific dsDNA endonuclease activity
                                    |__excinuclease ABC activity
                                    |__flap endonuclease activity 8 rec.
                                    |   |__3'-flap endonuclease activity 1 rec.
                                    |   |__5'-flap endonuclease activity 6 rec.
                                    |__restriction endodeoxyribonuclease activity
                                    |   |__type I site-specific deoxyribonuclease activity
                                    |   |__type II site-specific deoxyribonuclease activity
                                    |   |__type III site-specific deoxyribonuclease activity
                                    |   |__type IV site-specific deoxyribonuclease activity
                                    |__retroviral 3' processing activity
                                    |__single-stranded DNA endonuclease activity 17 rec.
                                    |   |__3' overhang single-stranded DNA endonuclease activity 2 rec.
                                    |   |__5' overhang single-stranded DNA endonuclease activity
                                    |__T/G mismatch-specific endonuclease activity
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Is a endonuclease activity
DNA nuclease activity
Part of
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Synonyms
  • "DNA nicking activity" RELATED
    "endodeoxyribonuclease activity" EXACT
    "endonuclease G activity" RELATED
Secondary IDs
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Reactome:R-HSA-110359 "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site"
Reactome:R-HSA-5686440 "MUS81:EME1,EME2 cleaves D-loop"
Reactome:R-HSA-5686657 "ERCC1:XPF cleaves flaps generated by SSA"
Reactome:R-HSA-5687464 "MRN and RBBP8 resect DNA DSBs in MMEJ"
Reactome:R-HSA-5690988 "3'-incision of DNA by ERCC5 (XPG) in GG-NER"
Reactome:R-HSA-5693584 "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)"
Reactome:R-HSA-5693608 "Initial resection of double-strand break ends"
Reactome:R-HSA-6782204 "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER"
Reactome:R-HSA-6782224 "3' incision by ERCC5 (XPG) in TC-NER"
Reactome:R-HSA-9023941 "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11"