FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term RNA endonuclease activity ID (Ontology) GO:0004521 (Gene Ontology)
Definition Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks.[ ISBN:0198547684 ]
Also Known As"endoribonuclease activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Gene Groups Genes
 RNA endonuclease activity (all annotations which use CV term, excluding "NOT" statements)
     enables | RNA endonuclease activity       --
 NOT | enables | RNA endonuclease activity       --
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Vocabulary search 
nuclease activity
 |__endonuclease activity__________
 |__RNA nuclease activity__________|
catalytic activity, acting on RNA  |
 |__RNA nuclease activity__________|
                                   RNA endonuclease activity  69 rec.
                                    |__Enterobacter ribonuclease activity
                                    |__ribonuclease A activity
                                    |__ribonuclease MRP activity 2 rec.
                                    |__ribonuclease T1 activity
                                    |__ribonuclease T2 activity 2 rec.
                                    |__ribonuclease U2 activity
                                    |__RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism
                                    |   |__ribonuclease F activity
                                    |   |__ribonuclease V activity
                                    |__RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism 23 rec.
                                    |   |__3'-tRNA processing endoribonuclease activity 1 rec.
                                    |   |__endoribonuclease activity, cleaving miRNA-paired mRNA 1 rec.
                                    |   |__endoribonuclease activity, cleaving siRNA-paired mRNA 1 rec.
                                    |   |__phosphodiesterase decapping endonuclease activity
                                    |   |__ribonuclease [poly-(U)-specific] activity
                                    |   |__ribonuclease E activity
                                    |   |__ribonuclease III activity 4 rec.
                                    |   |__ribonuclease IV activity
                                    |   |__ribonuclease IX activity
                                    |   |__ribonuclease M5 activity
                                    |   |__ribonuclease P activity 6 rec.
                                    |   |__ribonuclease P4 activity
                                    |   |__RNA lariat debranching enzyme activity 1 rec.
                                    |   |__RNA-(apurinic or apyrimidinic site) endonuclease activity
                                    |   |__RNA-DNA hybrid ribonuclease activity 6 rec.
                                    |__rRNA endonuclease activity
                                    |__tRNA-intron lyase activity 3 rec.
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Is a endonuclease activity
RNA nuclease activity
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Synonyms
  • "endonuclease G activity" RELATED
    "endoribonuclease activity" EXACT
Secondary IDs
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Reactome:R-HSA-425923 "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced"
Reactome:R-HSA-426520 "Endonucleolytic RISC hydrolyzes target RNAs"
Reactome:R-HSA-5601887 "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA"
Reactome:R-HSA-5601910 "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA"
Reactome:R-HSA-6791223 "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol"
Reactome:R-HSA-6814555 "Integrator complex processes the 3' end of snRNA"
Reactome:R-HSA-9009936 "RNASEL cleaves cellular ssRNA"
Reactome:R-HSA-9009941 "RNASEL cleaves viral ssRNA"
Reactome:R-HSA-9023909 "C3PO hydrolyzes cleaved passenger strand"
Reactome:R-HSA-9023912 "AGO2 cleaves passenger strand of duplex siRNA"
Reactome:R-HSA-927836 "SMG6 hydrolyzes mRNA with premature termination codon"
Reactome:R-HSA-9708327 "ANG cleaves tRNA to yield tRNA halves"
Reactome:R-HSA-9708812 "ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1)"
Reactome:R-HSA-9948427 "ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide"