FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term RNA-DNA hybrid ribonuclease activity ID (Ontology) GO:0004523 (Gene Ontology)
Definition Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.[ EC:3 ]
Also Known As "calf thymus ribonuclease H activity" ; "ribonuclease H activity" ; "RNase H activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 RNA-DNA hybrid ribonuclease activity (all annotations which use CV term, excluding "NOT" statements)
     enables | RNA-DNA hybrid ribonuclease activity       --
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RNA endonuclease activity__________________
hydrolase activity, acting on ester bonds__|
                                           RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism
                                            |__RNA-DNA hybrid ribonuclease activity  6 rec.
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Is a RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism
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Synonyms
  • "calf thymus ribonuclease H activity" EXACT
    "endoribonuclease H" RELATED[ EC:3 ]
    "endoribonuclease H (calf thymus)" RELATED[ EC:3 ]
    "endoribonuclease0 H activity" NARROW[ EC:3 ]
    "hybrid nuclease activity" RELATED[ EC:3 ]
    "hybrid ribonuclease activity" RELATED[ EC:3 ]
    "hybridase (ribonuclease H)" RELATED[ EC:3 ]
    "hybridase activity" RELATED[ EC:3 ]
    "ribonuclease H activity" EXACT
    "ribonuclease H1 activity" NARROW
    "ribonuclease H2 activity" NARROW
    "ribonuclease H3 activity" NARROW
    "RNA*DNA hybrid ribonucleotidohydrolase activity" RELATED[ EC:3 ]
    "RNase H activity" EXACT
    "RNase H1 activity" NARROW
    "RNase H2 activity" NARROW
    "RNase H3 activity" NARROW
Secondary IDs
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EC:3.1.26.4
MetaCyc:3.1.26.4-RXN
Reactome:R-HSA-164519 "RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex"
Reactome:R-HSA-164528 "RNase H-mediated cleavage of the template strand"
Reactome:R-HSA-173769 "RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers"
Reactome:R-HSA-182795 "RNase H-mediated degradation of the template strand"
Reactome:R-HSA-182859 "RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex"
Reactome:R-HSA-9913637 "RNASEH1 cleaves R-loop RNA to yield RNA primer for H strand polymerization"
Reactome:R-HSA-9914858 "RNASEH1 cleaves RNA primer from nascent H strand, leaving RNA dinucleotides"
Reactome:R-HSA-9915449 "RNASEH1 cleaves RNA primer from nascent L strand, leaving RNA dinucleotides"