FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term ribonuclease III activity ID (Ontology) GO:0004525 (Gene Ontology)
Definition Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.[ PubMed:11157775 PubMed:15242644 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 ribonuclease III activity (all annotations which use CV term, excluding "NOT" statements)
     enables | ribonuclease III activity       --
 NOT | enables | ribonuclease III activity       --
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RNA endonuclease activity
 |__RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism__
RNA nuclease activity                                                               |
 |__double-stranded RNA-specific ribonuclease activity______________________________|
hydrolase activity, acting on ester bonds                                           |
 |__RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism__|
 |__double-stranded RNA-specific ribonuclease activity______________________________|
                                                                                    ribonuclease III activity  4 rec.
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Is a RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism
double-stranded RNA-specific ribonuclease activity
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Synonyms
  • "pre-mRNA 3'-end processing endonuclease" NARROW
    "ribonuclease 3 activity" RELATED[ EC:3 ]
    "RNase III activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.1.26.3
MetaCyc:3.1.26.3-RXN
Reactome:R-HSA-203862 "Dicer cleaves pre-miRNA to yield duplex miRNA"
Reactome:R-HSA-203893 "Microprocessor complex cleaves pri-miRNA to pre-miRNA"
Reactome:R-HSA-426464 "Dicer cleaves double-stranded RNA to yield double-stranded siRNA"
Reactome:R-HSA-9708292 "DICER1 cleaves tRNA"
Reactome:R-HSA-9708408 "DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid"
Reactome:R-HSA-9820840 "DICER1 hydrolyzes maternal mRNA:lncRNA to yield endosiRNA"