FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

5'-3' RNA exonuclease activity

ID (Ontology)

GO:0004534 (Gene Ontology)

Definition

Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule.[ ISBN:0198547684 ]

Also Known As

"5'-3' exoribonuclease activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
5'-3' RNA exonuclease activity (all annotations which use CV term, excluding "NOT" statements)
enables \| 5'-3' RNA exonuclease activity	--

Spanning Tree (Parents/Children)

exonuclease activity
 |__5'-3' exonuclease activity________________________________
RNA exonuclease activity                                      |
 |__RNA exonuclease activity, producing 5'-phosphomonoesters__|
                                                              5'-3' RNA exonuclease activity  5 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	5'-3' exonuclease activity RNA exonuclease activity, producing 5'-phosphomonoesters
Part of
Synonyms & Secondary IDs
Synonyms
	"5'-3' exoribonuclease activity" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-429845 "5' to 3' exoribonuclease hydrolyzes decapped mRNA" Reactome:R-HSA-6791227 "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA" Reactome:R-HSA-9915442 "EXOG cleaves RNA dinucleotide from nascent mitochondrial DNA" Reactome:R-HSA-9935265 "DXO hydrolyzes uncapped RNA" Reactome:R-HSA-9935299 "XRN2 5'-3' exonucleolytically hydrolyzes uncapped RNA" Reactome:R-HSA-9946917 "XRN1 incompletely hydrolyzes DENV decapped mRNA" Reactome:R-HSA-9971054 "XRN2 degrades downstream RNA fragment, promoting transcription termination"