FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term poly(A)-specific ribonuclease activity ID (Ontology) GO:0004535 (Gene Ontology)
Definition Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.[ EC:3 ISBN:0198547684 ]
Also Known As"poly(A)-specific RNase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 poly(A)-specific ribonuclease activity (all annotations which use CV term, excluding "NOT" statements)
     enables | poly(A)-specific ribonuclease activity       --
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3'-5' exonuclease activity________________________________
RNA exonuclease activity, producing 5'-phosphomonoesters__|
                                                          3'-5'-RNA exonuclease activity
                                                           |__poly(A)-specific ribonuclease activity  6 rec.
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Is a 3'-5'-RNA exonuclease activity
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Synonyms
  • "2',3'-exoribonuclease activity" RELATED[ EC:3 ]
    "3'-exoribonuclease activity" RELATED[ EC:3 ]
    "poly(A)-specific RNase activity" EXACT
Secondary IDs
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EC:3.1.13.4
MetaCyc:3.1.13.4-RXN
Reactome:R-HSA-429955 "CCR4-NOT complex deadenylates mRNA"
Reactome:R-HSA-429992 "PARN deadenylates mRNA"
Reactome:R-HSA-430021 "PAN2-PAN3 complex partially deadenylates mRNA"
Reactome:R-HSA-9009950 "PDE12 cleaves 2'-5' oligoadenylates"
Reactome:R-HSA-9615042 "Viral 2',5'-PDE cleaves 2'-5' oligoadenylates"
Reactome:R-HSA-9822311 "CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP"
Reactome:R-HSA-9822335 "CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA"