FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term DNA nuclease activity ID (Ontology) GO:0004536 (Gene Ontology)
Definition Catalysis of the cleavage of ester linkages within deoxyribonucleic acid.[ ISBN:0198547684 ]
Also Known As"deoxyribonuclease activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 DNA nuclease activity (all annotations which use CV term, excluding "NOT" statements)
     enables | DNA nuclease activity       --
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catalytic activity, acting on a nucleic acid
 |__nuclease activity__________________
 |__catalytic activity, acting on DNA__|
                                       DNA nuclease activity  70 rec.
                                        |__DNA endonuclease activity 49 rec.
                                        |   |__deoxyribonuclease (pyrimidine dimer) activity
                                        |   |__DNA endonuclease activity, producing 3'-phosphomonoesters(+) 5 rec.
                                        |   |__DNA endonuclease activity, producing 5'-phosphomonoesters(+) 13 rec.
                                        |   |__DNA-(apurinic or apyrimidinic site) endonuclease activity(+) 10 rec.
                                        |   |__double-stranded DNA endonuclease activity(+) 13 rec.
                                        |   |__excinuclease ABC activity
                                        |   |__flap endonuclease activity(+) 8 rec.
                                        |   |__restriction endodeoxyribonuclease activity(+)
                                        |   |__retroviral 3' processing activity
                                        |   |__single-stranded DNA endonuclease activity(+) 17 rec.
                                        |   |__T/G mismatch-specific endonuclease activity
                                        |__DNA exonuclease activity 24 rec.
                                            |__DNA exonuclease activity, producing 5'-phosphomonoesters(+) 23 rec.
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Is a nuclease activity
catalytic activity, acting on DNA
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Synonyms
  • "caspase-activated deoxyribonuclease activity" NARROW
    "deoxyribonuclease activity" EXACT
Secondary IDs
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Reactome:R-HSA-211247 "Cleavage of DNA by DFF40"
Reactome:R-HSA-5685994 "Long-range resection of DNA DSBs by EXO1 or DNA2"
Reactome:R-HSA-6785986 "DNA nucleases unhook the interstrand crosslink (ICL)"