FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term beta-N-acetylhexosaminidase activity ID (Ontology) GO:0004563 (Gene Ontology)
Definition Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.[ EC:3 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 beta-N-acetylhexosaminidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | beta-N-acetylhexosaminidase activity       --
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  hydrolase activity, hydrolyzing O-glycosyl compounds
   |__hexosaminidase activity
       |__beta-N-acetylhexosaminidase activity  5 rec.
           |__beta-N-acetylgalactosaminidase activity
           |__beta-N-acetylglucosaminidase activity 3 rec.
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Is a hexosaminidase activity
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Synonyms
  • "beta-acetylaminodeoxyhexosidase activity" RELATED[ EC:3 ]
    "beta-acetylhexosaminidinase activity" RELATED[ EC:3 ]
    "beta-D-hexosaminidase activity" RELATED[ EC:3 ]
    "beta-D-N-acetylhexosaminidase activity" RELATED[ EC:3 ]
    "beta-hexosaminidase activity" RELATED[ EC:3 ]
    "beta-N-acetyl-D-hexosaminidase activity" RELATED[ EC:3 ]
    "beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity" RELATED[ EC:3 ]
    "hexosaminidase A" RELATED[ EC:3 ]
    "N-acetyl-beta-D-hexosaminidase activity" RELATED[ EC:3 ]
    "N-acetyl-beta-glucosaminidase activity" RELATED[ EC:3 ]
    "N-acetyl-beta-hexosaminidase activity" RELATED[ EC:3 ]
    "N-acetylhexosaminidase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.2.1.52
MetaCyc:3.2.1.52-RXN
Reactome:R-HSA-1605595 "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3"
Reactome:R-HSA-1605632 "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE"
Reactome:R-HSA-1638053 "HEXA cleaves the terminal GlcNAc from keratan sulfate"
Reactome:R-HSA-2105001 "HEXA cleaves the terminal GalNAc from DS"
Reactome:R-HSA-2162225 "HEXA cleaves the terminal GlcNAc from small HA fragments"
Reactome:R-HSA-9035976 "Defective HEXA does not cleave the terminall GalNAc from small HA fragments"
Reactome:R-HSA-9035982 "Defective HEXB does not cleave the terminal GalNAc from HA fragments"
Reactome:R-HSA-9638075 "HEXB cleaves the terminal GalNAc from DS"
Reactome:R-HSA-9638076 "HEXB cleaves the terminal GlcNAc from small HA fragments"
Reactome:R-HSA-9638078 "HEXB cleaves the terminal GlcNAc from keratan sulfate"
Reactome:R-HSA-9840833 "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer"
Reactome:R-HSA-9840884 "bHEXA,bHEXS hydrolyze GM2A:SM2"