FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ID (Ontology) GO:0004571 (Gene Ontology)
Definition Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.[ PubMed:25092655 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity       --
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  alpha-mannosidase activity
   |__mannosyl-oligosaccharide mannosidase activity
       |__mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  12 rec.
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Is a mannosyl-oligosaccharide mannosidase activity
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Synonyms
  • "1,2-alpha-mannosidase" RELATED[ EC:3 ]
    "1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" RELATED[ EC:3 ]
    "exo-alpha-1,2-mannanase activity" RELATED[ EC:3 ]
    "glycoprotein processing mannosidase I" RELATED[ EC:3 ]
    "Man9-mannosidase activity" NARROW[ EC:3 ]
    "ManI activity" NARROW[ EC:3 ]
    "mannose-9 processing alpha-mannosidase activity" NARROW[ EC:3 ]
    "mannosidase 1A activity" NARROW[ EC:3 ]
    "mannosidase 1B activity" NARROW[ EC:3 ]
    "mannosidase I" RELATED[ EC:3 ]
Secondary IDs
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EC:3.2.1.113
KEGG_REACTION:R12479
MetaCyc:RXN-18910
MetaCyc:RXN-18911
Reactome:R-HSA-4793949 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch)"
Reactome:R-HSA-6782685 "EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5"
Reactome:R-HSA-901024 "MAN1B1 hydrolyses 1,2-linked mannose (a branch)"
Reactome:R-HSA-901036 "MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)"
Reactome:R-HSA-901039 "MAN1B1 hydrolyses 1,2-linked mannose (c branch)"
Reactome:R-HSA-901074 "MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)"
Reactome:R-HSA-9036008 "Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch)"
Reactome:R-HSA-9036011 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch)"
Reactome:R-HSA-9036012 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch)"
Reactome:R-HSA-964737 "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2"
Reactome:R-HSA-964825 "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2"
Reactome:R-HSA-964830 "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2"
Reactome:R-HSA-9696807 "N-glycan mannose trimming of Spike"
RHEA:56008
RHEA:56028