FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term oxoglutarate dehydrogenase (succinyl-transferring) activity ID (Ontology) GO:0004591 (Gene Ontology)
Definition Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H+ = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2.
Also Known As "oxoglutarate dehydrogenase (lipoamide) activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 Gene Groups Genes
 oxoglutarate dehydrogenase (succinyl-transferring) activity (all annotations which use CV term, excluding "NOT" statements)       4      2
     enables | oxoglutarate dehydrogenase (succinyl-transferring) activity       --       2
Spanning Tree (Parents/Children)
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  oxidoreductase activity, acting on the aldehyde or oxo group of donors
   |__oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
       |__oxoglutarate dehydrogenase (succinyl-transferring) activity  6 rec.
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Is a oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
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Synonyms
  • "2-ketoglutarate dehydrogenase activity" RELATED[ EC:1 ]
    "2-oxoglutarate dehydrogenase activity" RELATED[ EC:1 ]
    "2-oxoglutarate: lipoate oxidoreductase activity" RELATED[ EC:1 ]
    "2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)" RELATED[ EC:1 ]
    "2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity" RELATED[ EC:1 ]
    "AKGDH activity" RELATED[ EC:1 ]
    "alpha-ketoglutarate dehydrogenase activity" RELATED[ EC:1 ]
    "alpha-ketoglutaric acid dehydrogenase activity" RELATED[ EC:1 ]
    "alpha-ketoglutaric dehydrogenase activity" RELATED[ EC:1 ]
    "alpha-oxoglutarate dehydrogenase activity" RELATED[ EC:1 ]
    "ketoglutaric dehydrogenase activity" RELATED[ EC:1 ]
    "OGDC activity" RELATED[ EC:1 ]
    "oxoglutarate decarboxylase activity" RELATED[ EC:1 ]
    "oxoglutarate dehydrogenase (lipoamide) activity" EXACT
    "oxoglutarate dehydrogenase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.2.4.2
MetaCyc:2OXOGLUTDECARB-RXN
Reactome:R-HSA-71401 "OGDH dimer decarboxylates 2-OG"
RHEA:12188