FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

protein-N-terminal amino-acid acetyltransferase activity

ID (Ontology)

GO:0004596 (Gene Ontology)

Definition

Catalysis of the reaction: acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-alpha-aminoacyl-[protein].[ PubMed:30054468 ]

Also Known As

"acetyl-CoA:peptide alpha-N-acetyltransferase activity" ; "acetyl-CoA:peptide nalpha-acetyltransferase activity" ; "nalpha-acetyltransferase activity" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
protein-N-terminal amino-acid acetyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| protein-N-terminal amino-acid acetyltransferase activity	--

Spanning Tree (Parents/Children)

N-acetyltransferase activity________
protein N-acyltransferase activity__|
                                    protein N-acetyltransferase activity
                                     |__protein-N-terminal amino-acid acetyltransferase activity  18 rec.
                                         |__protein N-terminal-methionine acetyltransferase activity
                                         |__protein N-terminal-serine acetyltransferase activity 1 rec.
                                         |__protein-N-terminal-alanine acetyltransferase activity
                                         |__protein-N-terminal-glutamate acetyltransferase activity
                                         |__tubulin N-terminal-methionine acetyltransferase activity 1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein N-acetyltransferase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"acetyl-CoA:peptide alpha-N-acetyltransferase activity" EXACT "acetyl-CoA:peptide nalpha-acetyltransferase activity" EXACT "amino-terminal amino acid-acetylating enzyme activity" RELATED "beta-endorphin acetyltransferase activity" NARROW "N(alpha)-acetyltransferase activity" RELATED "nalpha-acetyltransferase activity" EXACT "NAT activity" RELATED "peptide acetyltransferase activity" RELATED "peptide alpha-N-acetyltransferase activity" EXACT "protein N-terminal acetyltransferase activity" EXACT
Secondary IDs

External Crossreferences & Linkouts
	EC:2.3.1.255 Reactome:R-HSA-6814090 "NatC acetylates ARFFRP1" RHEA:21028 RHEA:50508 RHEA:50512 RHEA:50516 RHEA:57320 RHEA:57324 RHEA:57328 RHEA:75243 RHEA:75247