FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term glutathione peroxidase activity ID (Ontology) GO:0004602 (Gene Ontology)
Definition Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.[ EC:1 PubMed:36771108 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 glutathione peroxidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | glutathione peroxidase activity       --
 NOT | enables | glutathione peroxidase activity       --
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antioxidant activity_____________________________________
oxidoreductase activity, acting on peroxide as acceptor__|
                                                         peroxidase activity
                                                          |__glutathione peroxidase activity  16 rec.
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Is a peroxidase activity
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Synonyms
  • "glutathione:hydrogen-peroxide oxidoreductase activity" RELATED[ EC:1 ]
    "GSH peroxidase activity" RELATED[ EC:1 ]
    "non-selenium glutathione peroxidase activity" NARROW
    "reduced glutathione peroxidase activity" RELATED[ EC:1 ]
    "selenium-glutathione peroxidase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.11.1.9
MetaCyc:GLUTATHIONE-PEROXIDASE-RXN
Reactome:R-HSA-2161791 "15S-HpETE is reduced to 15S-HETE by GPX1/2/4"
Reactome:R-HSA-2161946 "5S-HpETE is reduced to 5S-HETE by GPX1/2/4"
Reactome:R-HSA-2161959 "12R-HpETE is reduced to 12R-HETE by GPX1/2/4"
Reactome:R-HSA-2161999 "12S-HpETE is reduced to 12S-HETE by GPX1/2/4"
Reactome:R-HSA-3323013 "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O"
Reactome:R-HSA-3341277 "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O"
Reactome:R-HSA-3341397 "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O"
Reactome:R-HSA-3343700 "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O"
Reactome:R-HSA-6799695 "GPX5,6 reduce H2O2 to H2O"
Reactome:R-HSA-71676 "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O"
RHEA:16833