FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term phosphoglycerate dehydrogenase activity ID (Ontology) GO:0004617 (Gene Ontology)
Definition Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.[ EC:1 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 phosphoglycerate dehydrogenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | phosphoglycerate dehydrogenase activity
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  oxidoreductase activity, acting on CH-OH group of donors
   |__oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
       |__phosphoglycerate dehydrogenase activity  1 rec.
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Is a oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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Synonyms
  • "3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity" RELATED[ EC:1 ]
    "3-phosphoglycerate dehydrogenase activity" RELATED[ EC:1 ]
    "3-phosphoglycerate:NAD+ 2-oxidoreductase activity" RELATED[ EC:1 ]
    "3-phosphoglyceric acid dehydrogenase activity" RELATED[ EC:1 ]
    "3PHP reductase activity" RELATED[ EC:1 ]
    "alpha-KG reductase activity" RELATED[ EC:1 ]
    "alpha-phosphoglycerate dehydrogenase activity" RELATED[ EC:1 ]
    "alphaKG reductase activity" RELATED[ EC:1 ]
    "D- and L-HGA" RELATED[ EC:1 ]
    "D-3-phosphoglycerate dehydrogenase activity" RELATED[ EC:1 ]
    "D-3-phosphoglycerate:NAD+ oxidoreductase activity" RELATED[ EC:1 ]
    "glycerate 3-phosphate dehydrogenase activity" RELATED[ EC:1 ]
    "glycerate-1,3-phosphate dehydrogenase activity" RELATED[ EC:1 ]
    "PGDH activity" RELATED[ EC:1 ]
    "phosphoglycerate oxidoreductase activity" RELATED[ EC:1 ]
    "phosphoglyceric acid dehydrogenase activity" RELATED[ EC:1 ]
    "SerA" RELATED[ EC:1 ]
    "SerA 3PG dehydrogenase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.1.1.95
MetaCyc:PGLYCDEHYDROG-RXN
Reactome:R-HSA-977348 "PHGDH tetramer dehydrogenates 3PG"
RHEA:12641