FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term A2-type glycerophospholipase activity ID (Ontology) GO:0004623 (Gene Ontology)
Definition A glycerophospholipase activity that cleaves the fatty acid attached to the sn-2 position of the glycerol group of a glycerophospholipid. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.[ PubMed:30109646 ]
Also Known As "phospholipase A2 activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 A2-type glycerophospholipase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | A2-type glycerophospholipase activity       --
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hydrolase activity, acting on ester bonds
 |__carboxylic ester hydrolase activity__
phospholipase activity                   |
 |__glycerophospholipase activity________|
                                         A2-type glycerophospholipase activity  13 rec.
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Is a glycerophospholipase activity
carboxylic ester hydrolase activity
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Synonyms
  • "cytosolic phospholipase A2 activity" NARROW
    "lecithinase A activity" RELATED[ EC:3 ]
    "phosphatidase activity" RELATED[ EC:3 ]
    "phosphatidolipase activity" RELATED[ EC:3 ]
    "phosphatidylcholine 2-acylhydrolase activity" RELATED[ EC:3 ]
    "phospholipase A2 activity" EXACT
    "phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)" NARROW
    "phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" NARROW
    "secreted phospholipase A2 activity" NARROW
Secondary IDs
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EC:3.1.1.4
MetaCyc:PHOSPHOLIPASE-A2-RXN
MetaCyc:RXN-15065
MetaCyc:RXN-15067
Reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)"
Reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]"
Reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A"
Reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)"
Reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)"
Reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]"
Reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A"
Reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)"
Reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]"
Reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]"
Reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]"
Reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]"
Reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]"
Reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]"
Reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]"
Reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]"
Reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A"
Reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]"
Reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]"
Reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]"
Reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]"
Reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1"
Reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]"
Reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]"
Reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane"
RHEA:15801
RHEA:38779
RHEA:38847
RHEA:40427
RHEA:40519
RHEA:40643
RHEA:40651
RHEA:40811
RHEA:41223
RHEA:53500
RHEA:56428
RHEA:62036