FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term C-type glycerophospholipase activity ID (Ontology) GO:0004629 (Gene Ontology)
Definition A glycerophospholipase activity that cleaves the first phosphodiester bond between the phosphate and glycerol, producing a mono- or a diacylglycerol, depending on whether the substrate is a lysoglycerophospholipid or a glycerophospholipid.[ PubMed:30109646 ]
Also Known As"C-type phospholipase activity" ; "phospholipase C activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 C-type glycerophospholipase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | C-type glycerophospholipase activity       --
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phosphoric ester hydrolase activity
 |__phosphoric diester hydrolase activity__
phospholipase activity                     |
 |__glycerophospholipase activity__________|
                                           C-type glycerophospholipase activity  6 rec.
                                            |__GPI anchor phospholipase C activity
                                            |__lysophospholipase C activity
                                            |__phosphatidylcholine phospholipase C activity 1 rec.
                                            |__phosphatidylglycerol phospholipase C activity
                                            |__phosphatidylinositol phospholipase C activity 1 rec.
                                            |__phosphatidylinositol-4,5-bisphosphate phospholipase C activity 3 rec.
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Is a glycerophospholipase activity
phosphoric diester hydrolase activity
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Synonyms
  • "C-type phospholipase activity" EXACT
    "phosphatidase C" RELATED
    "phospholipase C activity" EXACT
Secondary IDs
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Reactome:R-HSA-1112666 "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate"
Reactome:R-HSA-114688 "PLC-beta hydrolyses PIP2 to DAG and IP3"
Reactome:R-HSA-114689 "PLC gamma 2-mediated PIP2 hydrolysis"
Reactome:R-HSA-398193 "PLC beta-mediated PIP2 hydrolysis"
Reactome:R-HSA-399998 "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate"
Reactome:R-HSA-5362553 "NOTUM releases Hh-Np:GPC5 from the plasma membrane"