FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term phosphoribosylformylglycinamidine cyclo-ligase activity ID (Ontology) GO:0004641 (Gene Ontology)
Definition Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate.[ EC:6 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 phosphoribosylformylglycinamidine cyclo-ligase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | phosphoribosylformylglycinamidine cyclo-ligase activity
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Vocabulary search: maintenance 
  ligase activity, forming carbon-nitrogen bonds
   |__cyclo-ligase activity
       |__phosphoribosylformylglycinamidine cyclo-ligase activity  1 rec.
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Is a cyclo-ligase activity
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Synonyms
  • "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" RELATED[ EC:6 ]
    "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" RELATED[ EC:6 ]
    "5'-aminoimidazole ribonucleotide synthetase activity" RELATED[ EC:6 ]
    "AIR synthase activity" RELATED[ EC:6 ]
    "AIR synthetase activity" RELATED[ EC:6 ]
    "AIRS activity" RELATED[ EC:6 ]
    "phosphoribosyl-aminoimidazole synthetase activity" RELATED[ EC:6 ]
    "phosphoribosylaminoimidazole synthetase activity" RELATED[ EC:6 ]
Secondary IDs
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EC:6.3.3.1
KEGG_REACTION:R04208
MetaCyc:AIRS-RXN
Reactome:R-HSA-73810 "FGAM + ATP => AIR + ADP + Pi"
RHEA:23032