FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term phosphoribosylformylglycinamidine synthase activity ID (Ontology) GO:0004642 (Gene Ontology)
Definition Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate.[ EC:6 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 phosphoribosylformylglycinamidine synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | phosphoribosylformylglycinamidine synthase activity
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  ligase activity, forming carbon-nitrogen bonds
   |__carbon-nitrogen ligase activity, with glutamine as amido-N-donor
       |__phosphoribosylformylglycinamidine synthase activity  1 rec.
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Is a carbon-nitrogen ligase activity, with glutamine as amido-N-donor
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Synonyms
  • "2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" RELATED[ EC:6 ]
    "5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)" RELATED[ EC:6 ]
    "FGAM synthase activity" RELATED[ EC:6 ]
    "FGAM synthetase activity" RELATED[ EC:6 ]
    "FGAR amidotransferase activity" RELATED[ EC:6 ]
    "FGARAT activity" RELATED[ EC:6 ]
    "formylglycinamide ribonucloetide amidotransferase activity" RELATED[ EC:6 ]
    "formylglycinamide ribotide amidotransferase activity" RELATED[ EC:6 ]
    "N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" RELATED[ EC:6 ]
    "phosphoribosylformylglycinamidine synthetase activity" RELATED[ EC:6 ]
    "phosphoribosylformylglycineamidine synthetase activity" RELATED[ EC:6 ]
Secondary IDs
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EC:6.3.5.3
KEGG_REACTION:R04463
MetaCyc:FGAMSYN-RXN
Reactome:R-HSA-73812 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi"
RHEA:17129