FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term polypeptide N-acetylgalactosaminyltransferase activity ID (Ontology) GO:0004653 (Gene Ontology)
Definition Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.[ EC:2 ISBN:0879695595 ]
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      12
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 polypeptide N-acetylgalactosaminyltransferase activity (all annotations which use CV term, excluding "NOT" statements)       1     12
     enables | polypeptide N-acetylgalactosaminyltransferase activity       --      12
 NOT | enables | polypeptide N-acetylgalactosaminyltransferase activity       --       2
Spanning Tree (Parents/Children)
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catalytic activity
 |__catalytic activity, acting on a protein___
UDP-glycosyltransferase activity              |
 |__acetylgalactosaminyltransferase activity__|
hexosyltransferase activity                   |
 |__acetylgalactosaminyltransferase activity__|
                                              polypeptide N-acetylgalactosaminyltransferase activity  13 rec.
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Is a acetylgalactosaminyltransferase activity
catalytic activity, acting on a protein
Part of
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Synonyms
  • "glycoprotein acetylgalactosaminyltransferase activity" RELATED[ EC:2 ]
    "polypeptide-N-acetylgalactosamine transferase activity" RELATED[ EC:2 ]
    "protein-UDP acetylgalactosaminyltransferase activity" RELATED[ EC:2 ]
    "UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" RELATED[ EC:2 ]
    "UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity" RELATED[ EC:2 ]
    "UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity" RELATED[ EC:2 ]
    "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity" RELATED[ EC:2 ]
    "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity" RELATED[ EC:2 ]
    "UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity" RELATED[ EC:2 ]
    "UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity" RELATED[ EC:2 ]
    "UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity" RELATED[ EC:2 ]
    "UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity" RELATED[ EC:2 ]
    "UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity" RELATED[ EC:2 ]
    "UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity" RELATED[ EC:2 ]
    "uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.4.1.41
MetaCyc:2.4.1.41-RXN
Reactome:R-HSA-5096532 "Defective GALNT12 does not transfer GalNAc to mucins"
Reactome:R-HSA-5096537 "Defective GALNT3 does not transfer GalNAc to mucins"
Reactome:R-HSA-8851619 "GALNT3 transfers GalNAc to FGF23"
Reactome:R-HSA-913675 "GALNTs transfer GalNAc to Mucins to form Tn antigens"
Reactome:R-HSA-9683760 "GalNAc is transferred onto 3a"
Reactome:R-HSA-9694438 "GalNAc is transferred onto 3a"